Murli Kale was born into a family deeply connected to Meher Baba—his father Kalemama was one of Baba's closest disciples who had met four Perfect Masters, and his elder brother Shridhar also became part of Baba's mandali. At the end of December 1926, at age thirteen, Murli was sent with his elder brother Shridhar by their father to the boys' school Baba had reopened at Arangaon (the Meher Ashram of 1927), where Baba personally nurtured young souls in spiritual awakening.

After completing his education, Murli trained as a homeopathic doctor and served at the Meherabad Ashram dispensary, treating the mandali and poor villagers from surrounding areas. His medical skills would prove valuable throughout his life of service.

In 1949, Murli accepted the stringent conditions of Meher Baba's New Life and became one of the select companions who wandered with Baba across India in a state of complete renunciation. What distinguished Murli among the companions was his unfailing cheerfulness despite the hardships. Baba publicly praised him with extraordinary recognition: after six months of the New Life, Baba turned to Murli and praised him 'with all the dignity and solemnity at his command' for his exemplary behavior. In the words of the New Life circular, Murli's 'consistent cheerful and jolly mood was the bright spot for the companions through all the ups and downs and other trying vicissitudes of the New Life.' In a remarkable gesture, Baba folded his hands to Murli as a salaam in recognition of his bravery and brilliant merits—an honor that moved all present.

Baba had also arranged for Murli's passport, intending for him to study higher homeopathy in England, though this plan never materialized. On 1 July 1951 Baba released Murli from the New Life, and through New Life Circular No. 27 permitted him to settle in Jabalpur and practice homeopathy; he moved there in 1952. There he established the Meher Charitable Dispensary, serving patients while introducing many seekers to Meher Baba's love.

A touching story reveals the special bond between Murli's family and Baba. When his son Niket was born, Murli sent a unique letter to Baba—written from the newborn himself, with the baby's tiny thumb impression. Baba responded with delight, acknowledging it was perhaps the first time He was writing a letter to a child not even a month old. Baba gave the child the name 'Meheroba.'

Murli continued visiting Baba during darshan programs and remained a source of joy and inspiration for Baba lovers in Jabalpur. On February 6, 1977, Murli became one with his Beloved. His son Niket married Meera, daughter of Baba's well-known disciple Pankhraj, continuing the family's legacy of devotion through the TrustMeher organization.